Curcumin played an anti-cancer role in colorectal cancer via mediating circ_KIAA1199-related regulatory axis

Curcumin has been found to have anti-cancer role in many cancer, including colorectal cancer (CRC). However, it is not clear whether curcumin can be involved CRC progression by mediating the circRNA regulatory axis. inhibited proliferation, migration, invasion, and promoted apoptosis of cells. Circ_KIAA1199 was an upregulated CRC, its overexpression could reverse negative regulation on progression. MiR-433-3p sponged circ_KIAA1199, mimic abolished circ_KIAA1199 curcumin-treated ADAM10 a target miR-433-3p expression regulated curcumin. The suppressive effect inhibitor cells reversed silencing. Also, reduced tumor growth regulating circ_KIAA1199/miR-433-3p/ADAM10 axis vivo. Our data showed that restrain progression, which achieved through pathway.